TABLE 2.
The percent of survival neurons of mice brain in the cerebral cortex and various area of the hippocampus that recorded in different experimental groups.
| Group | Survival rate (%) | |||||
|---|---|---|---|---|---|---|
| Cerebral cortex | CA1 | CA2 | CA3 | CA4 | DG | |
| Sham control | 98.2 ± 1.7 | 97.5 ± 1.1 | 98.9 ± 1.0 | 97.8 ± 1.3 | 99.11 ± 1.0 | 96.6 ± 0.7 |
| STZ model | 23.4 ± 5.3**** | 31.0 ± 1.0**** | 23.3 ± 1.6**** | 35.4 ± 2.3**** | 30.9 ± 1.3**** | 23.9 ± 3.2**** |
| STZ + Pioglitazone | 79.7 ± 2.5****#### | 95.7 ± 0.9#### | 94.6 ± 1.2***#### | 91.6 ± 1.1****#### | 79.6 ± 1.2****#### | 90.4 ± 1.4****#### |
| STZ + PFT (100 mg/kg) | 91.1 ± 1.5**#### | 93.9 ± 0.9****#### | 91.6 ± 1.4****#### | 89.9 ± 0.9****#### | 76.1 ± 1.4****#### | 88.5 ± 1.4****#### |
| STZ + PFT (200 mg/kg) | 89.5 ± 1.3****#### | 95.3 ± 1.3*#### | 94.5 ± 1.5***#### | 90.8 ± 0.9****#### | 92.5 ± 2.0****#### | 92.3 ± 1.5***#### |
| STZ + PFT (400 mg/kg) | 91.8 ± 2.1**#### | 95.8 ± 1.1#### | 95.5 ± 2.0**#### | 93.3 ± 2.0****#### | 94.0 ± 1.5****#### | 91.3 ± 1.3**#### |
Data of survival rate represents the mean ± SD of three mice per group; * significantly different from the sham control group at p < 0.05, **significantly different from the sham control group at p < 0.01, ***significantly different from the sham control group at p < 0.001, *****significantly different from the sham control group at p < 0.0001, ####significantly different from the STZ group at p < 0.0001 using One-Way ANOVA followed by Tukey’s multiple comparisons test.