Table 3.

Summary of hub proteins identified from protein–protein interactions analysis of encoded differentially expressed genes in PAH disease.

Symbol	Description	Feature
HSP90AA1	Heat shock protein	Influenced the progression of pulmonary disease (Deng et al., 2021).
ANGPT2	Protein marker and mediator	Participated in the direct regulation of inflammation-related signal pathways in PAH (Zhong et al., 2018).
HSPD1	Heat shock protein	Involved in pulmonary disease as differential expression gene (Maremanda et al., 2020).
HSPH1	Heat shock protein	Interacted with STAT3 and enhanced its phosphorylation in acute lung injury (Liang et al., 2020).
TTN	TITIN protein	Served as a pathogenic gene associated with total anomalous pulmonary venous connection (Shi et al., 2018).
SPP1	Secreted phosphoprotein	Activated the idiopathic pulmonary fibrosis myofibroblasts in lung fibrosis (Morse et al., 2019).
SMC4	A core subunit of condensin complexes	Enriched in facilitating mitotic cell cycle process in PAH (Luo et al., 2020).
EEA1	Early endosome antigen-1	Contained sorting endosomes which marked early endosomes (Chrifi et al., 2019).
DKC1	Dyskeratosis congenita 1	Encoded the protein dyskerin and maintained telomeres in pulmonary disease (Khincha et al., 2014).