Table 4.
Summary of the regulatory biomolecules [transcription factors (TFs), miRNAs] of DEGs in PAH disease identified from the interactions of DEGs with TFs and DEGs with miRNAs.
| Symbol | Description | Feature |
|---|---|---|
| TFs | ||
| FOXC1 | Forkhead box C1 | Afflicted with PAH (Yang et al., 2020). |
| FOXL1 | Forkhead box L1 | Afflicted with PAH (Stankiewicz et al., 2009). |
| GATA2 | GATA binding protein 2 | Afflicted with PAH (Jouneau et al., 2017). |
| YY1 | YY1 transcription factor | Afflicted with PAH (Zhang L. et al., 2021). |
| SRF | Serum response factor | Afflicted with PAH (Ding et al., 2017). |
| miRNAs | ||
| hsa-mir-17-5p | MicroRNA 17 | Hypoxia-induced pulmonary vascular smooth muscle cell proliferation in PAH (Liu et al., 2018). |
| hsa-mir-26b-5p | MicroRNA 26 | Afflicted with PAH (Chouvarine et al., 2020). |
| hsa-mir-122-5p | MicroRNA 122 | Have a good diagnostic performance in PAH (Zhang et al., 2018). |
| hsa-mir-20a-5p | MicroRNA 20 | Promoted pulmonary artery smooth muscle cell proliferation in PAH (Zhou et al., 2020). |
| hsa-mir-106b-5p | MicroRNA 106 | Suppress the migration of pulmonary artery smooth muscle cell in PAH (Chen et al., 2020). |