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. 2021 Jul 23;22(15):7862. doi: 10.3390/ijms22157862

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Timeline for each experiment after neonatal hypoxia-ischemia (HI) of the brain. (A) Location of injected adipose-derived-mesenchymal stem cells (AD-MSCs) in the brain (A(i), postnatal day (PN) 7–17; A(ii), PN8–18). (B) Effect of treatment with AD-MSCs on the absolute number of all medium-spiny neurons (MSNs, B(i)), and the absolute number of progenitors that had differentiated into MSNs (B(ii)), in the caudate-putamen (CPu) at PN21. (C) Effect of treatment with AD-MSCs on cellular proliferation in the dorsolateral subventricular zone (dlSVZ) and the absolute number of microglia in the CPu and dlSVZ (C(i), PN7–17; C(ii), PN8–18). BrdU, bromodeoxyuridine.