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. 2021 Jul 23;22(15):7874. doi: 10.3390/ijms22157874

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Action potential characteristics and I_Ca,L in control, son and father iPSC-CMs. (A) Representative APs of control, son and father iPSC-CMs. (B–H) Summary of AP parameters in control and LMNA-mutated iPSC-CMs: (B) APA, (C) AP peak, (D) dV/dt_max, (E) APD₂₀, (F) APD₅₀, (G) APD₉₀ and (H) MDP. Control (FSE-5 m and 24.5), n = 30; son, n = 14; father, n = 27. One-way ANOVA was performed followed by Holm–Sidak post hoc analysis. * p < 0.05. (I) Representative recordings of the I_Ca,L in control, son and father iPSC-CMs. (J) I_Ca,L current–voltage (I–V) relations in control and LMNA-mutated iPSC-CMs (n = 13 control (FSE-5 m); n = 8 son; n = 13 father). Two-way ANOVA was performed followed by Holm–Sidak post hoc analysis. * p < 0.05 father vs. control; # p <0.05 son vs. control.