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. 2021 Jul 23;22(15):7874. doi: 10.3390/ijms22157874

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Altered gene expression in LMNA-mutated iPSC-CMs. (A) Expression of genes involved in Ca²⁺ handling in LMNA-mutated iPSC-CMs compared to control. * padj < 0.05 LMNA-mutated vs. control. (B) Schematic illustration of a LMNA-mutated cardiomyocyte showing the expected effect of its altered gene expression on key Ca²⁺ handling proteins: LTCC, plasma membrane Ca²⁺ ATPase (PMCA), NCX, RyR2, calsequestrin 2 (CASQ2), triadin (TRDN), junctin (JCN), calstabin2, SERCA2, phospholamban (PLN) and mitochondrial Ca²⁺ uniporter (MCU). Green indicates upregulation; Red indicates downregulation. White indicates gene expression alteration which is not statistically significant.