Table 3.

Symptoms and diagnostic tests according to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) seroprevalence and symptoms in Manaus, Amazonas, Brazil.

Characteristics	Variables	Total	Column %	IgG positive	Prevalencerow %	P-valueχ2 test	IgG positive and symptomsb	Prevalencerow %	P-valueχ2 test
Total		3046		886	29.10		725	23.84
Symptoms
Flu-like symptoms in last 7 days	No	2479	82.61	716	28.89	0.474	—	—
	Yes	522	17.39	159	30.46
Flu-like symptoms since March (any)	No	685	22.52	163	23.80	0.001	—	—
	Yes	2357	77.48	722	30.65
Which symptoms	Anosmia	525	22.27	341	64.95	<0.001	—	—
	Body aches	971	41.20	372	38.35	<0.001	—	—
	Chest pain	337	14.30	138	41.07	<0.001	—	—
	Chills	343	14.55	156	45.48	<0.001	—	—
	Conjunctivitis	61	2.59	19	31.15	0.200	—	—
	Cough	842	35.72	304	36.10	<0.001	—	—
	Diarrhoea	655	27.79	206	31.45	0.002	—	—
	Fever	717	30.42	318	44.41	<0.001	—	—
	Headache	1633	69.28	508	31.13	<0.001	—	—
	Lack of appetite	339	14.38	178	52.66	<0.001	—	—
	Palpitations	239	10.14	76	31.80	0.015	—	—
	Shortness of breath	487	20.66	175	35.93	<0.001	—	—
	Side chest pain	612	25.97	224	36.66	<0.001	—	—
	Skin rashes	130	5.52	45	34.62	0.009	—	—
	Sore throat	1049	44.51	315	30.06	0.004	—	—
	Vomiting	140	5.94	44	31.43	<0.001	—	—
Prior COVID-19 diagnosis
Prior SARS-CoV-2 RT-PCR	No	2788	92.35	798	28.63	<0.001	647	23.21	<0.001
	Yes, negative	172	5.70	40	23.26		36	20.93
	Yes, positive	59	1.95	42	71.19		37	62.71
Prior serological test	No	2349	77.76	660	28.11	<0.001	528	22.49	<0.001
	Yes, negative	531	17.58	116	21.85		103	19.40
	Yes, positive	141	4.67	103	73.05		89	63.12
Prior COVID-19 diagnosisc	No	2771	91.72	728	26.28	<0.001	588	21.23	<0.001
	Yes	250	8.28	154	61.60		135	54.00
Took medications after COVID-19 diagnosis	No	109	43.60	51	46.79	<0.001	43	39.45	<0.001
	Yes	141	56.40	103	73.05		92	65.25
Which medications	Nitazoxanide	11	7.80	10	90.91	0.008a	10	90.91	0.002a
	Azithromycin	108	76.60	78	72.22	<0.001	70	64.81	<0.001
	Hydroxy/chloroquine	27	19.15	19	70.37	0.028	17	62.96	0.028
	Corticosteroids	36	25.53	28	77.78	0.001	26	72.22	0.001
	Ivermectin	77	54.61	52	67.53	0.005	47	61.04	0.004
	Paracetamol	59	41.84	46	77.97	<0.001	44	74.58	<0.001
	Others	38	26.95	28	73.68	0.004	25	65.79	0.005

IgG, immunoglobulin G; COVID-19, coronavirus disease 2019; RT-PCR, reverse transcriptase polymerase chain reaction.

^aFisher´s exact test.

^bParticipants who had both SARS-CoV-2 IgG positive test and reported symptoms prior to recruitment since March 2020.

^cPrevious COVID-19 diagnosis was defined as individuals positive for SARS-CoV-2 RT-PCR or SARS-CoV-2 serological test or clinical diagnosis as COVID-19.