TABLE 2.

Top most significant DEGs in oocytes from primordial follicles between in vivo and in vitro groups.

Gene name	Description	Log2FC	p-Value	TPM	Up/Down Regulated	Function
Cdk10	Cyclin-dependent kinase 10	–49.56	1.04E-61	9.67	Down	Cell cycle
Ogfr	Opioid growth factor receptor-like protein	-46.32	1.93E-61	12.11	Down
Cyren	Cell cycle regulator of non-homologous end joining	–35.54	1.77E-31	0.47	Down
Ralb	RAS Like Proto-Oncogene B	–34.99	1.48E-27	0.82	Down
Psmg2	Proteasome Assembly Chaperone 2	–38.92	8.71E-13	5.91	Down
Pura	Purine Rich Element Binding Protein A	–26.19	9.33E-23	18.77	Down	TGF-beta signaling
Snx25	Sorting Nexin 25	–19.64	3.95E-15	4.48	Down
Smad7	SMAD Family Member 7	42.25	1.12E-34	10.38	Up
Wnt2b	Wnt Family Member 2	–40.34	1.85E-20	13.30	Down	Wnt signaling
Wnt5a	Wnt Family Member 5A	–20.62	5.60E-05	5.18E-07	Down
Mgat3	Beta-1,4-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase	–33.28	5.63E-14	18.44	Down
Fzd1	Frizzled Class Receptor 1	–10.76	0.002	25.61	Down
Fzd2	Frizzled Class Receptor 2	40.55	2.94E-30	7.35	Up
Map2k3	Mitogen-Activated Protein Kinase Kinase 3	–47.27	4.65E-50	13.18	Down	Signal transduction
Slc25a10	Solute Carrier Family 25 Member 10	–41.37	5.35E-42	5.13	Down	Mitochondria
Miga2	Mitoguardin 2	–40.64	9.23E-33	5.30	Down
Timm21	Translocase of Inner Mitochondrial Membrane 21	–24.19	3.32E-21	76.91	Down
Timm8a1	Translocase of Inner Mitochondrial Membrane 8A	–19.01	3.57E-09	11.46	Down
Dcxr	Dicarbonyl and L-Xylulose Reductase	–39.55	1.66E-22	2.70	Down	ROS signaling
Foxred1	FAD Dependent Oxidoreductase Domain Containing 1	–34.28	1.10E-09	0.83	Down
Nox4	NADPH Oxidase 4	–33.39	3.60E-12	0.58	Down
Zgpat	Zinc finger CCCH-type with G patch domain-containing protein	–47.742685	7.38E-58	1.45517695	Down	Transcription
Gstm4	Glutathione S-transferase Mu 4	–33.60	1.02E-10	40.25	Down	Metabolism
Abcd2	ATP-binding cassette sub-family D member 2	30.056805	1.18E-06	1.50857192	Up	Transport