Table 2.
Clinical features of patients with NSCLC who are with or without genetic alterations of m6A regulators.
| Parameters | With mutation and/or CNVs | Without mutation and/or CNVs | P value | |
|---|---|---|---|---|
| Age | ≤60 | 90 | 176 | 0.217 |
| >60 | 223 | 524 | ||
|
| ||||
| Gender | Female | 123 | 283 | 0.787 |
| Male | 190 | 417 | ||
|
| ||||
| Primary diagnosis | Acinar cell carcinoma | 6 | 16 | 0.07 |
| Adenocarcinoma, NOS | 102 | 210 | ||
| Adenocarcinoma with mixed subtypes | 37 | 71 | ||
| Basaloid squamous cell carcinoma | 5 | 9 | ||
| Bronchiolo-alveolar carcinoma, mucinous | 2 | 3 | ||
| Bronchiolo-alveolar adenocarcinoma, NOS | 1 | 2 | ||
| Bronchiolo-alveolar carcinoma, nonmucinous | 6 | 12 | ||
| Clear cell adenocarcinoma, NOS | 1 | 1 | ||
| Micropapillary carcinoma, NOS | 0 | 3 | ||
| Mucinous adenocarcinoma | 1 | 12 | ||
| Papillary adenocarcinoma, NOS | 6 | 16 | ||
| Papillary squamous cell carcinoma | 1 | 3 | ||
| Signet ring cell carcinoma | 0 | 1 | ||
| Solid carcinoma, NOS | 2 | 4 | ||
| Squamous cell carcinoma, keratinizing, NOS | 3 | 9 | ||
| Squamous cell carcinoma, small cell, nonkeratinizing | 1 | 3 | ||
| Squamous cell carcinoma, NOS | 139 | 325 | ||
|
| ||||
| Tumor stage | Not reported | 3 | 8 | 0.001 ∗ |
| Stage I-II | 242 | 559 | ||
| Stage III-IV | 68 | 133 | ||
|
| ||||
| Tissue or organ of origin | Lower lobe, lung | 99 | 251 | 0.137 |
| Lung, NOS | 14 | 37 | ||
| Main bronchus | 4 | 5 | ||
| Middle lobe, lung | 14 | 23 | ||
| Overlapping lesion of lung | 6 | 5 | ||
| Upper lobe, lung | 176 | 379 | ||
NOS, not otherwise specified.