Table 1.

Neutralizing AAV responses elicited by AAVCOVID in NHP

Animal	Time (weeks)	AAVrh32.33	AAV1	AAV2	AAV5	AAV8	AAV9
AC1 NHP#1	0	< 5	< 5	< 5	< 5	5	< 5
	4	< 5	< 5	< 5	< 5	< 5	< 5
	8	< 5	< 5	< 5	< 5	< 5	< 5
	12	20	< 5	< 5	< 5	< 5	< 5
	14/16/20	80/80/160	N/A	N/A	N/A	N/A	N/A
AC1 NHP#2	0	< 5	< 5	< 5	< 5	< 5	< 5
	4	10	< 5	< 5	< 5	< 5	< 5
	8	160	< 5	< 5	< 5	< 5	< 5
	12	320	< 5	< 5	< 5	< 5	< 5
	14/16/20	320/320/320	N/A	N/A	N/A	N/A	N/A
AC3 NHP#3	0	< 5	< 5	< 5	< 5	< 5	< 5
	4	< 5	< 5	< 5	< 5	< 5	< 5
	8	40	< 5	< 5	< 5	< 5	N/A
	12	160	< 5	< 5	< 5	< 5	< 5
	14/16/20	160/160/160	N/A	N/A	N/A	N/A	N/A
AC3 NHP#4	0	< 5	< 5	< 5	< 5	< 5	< 5
	4	5	< 5	< 5	< 5	< 5	< 5
	8	40	< 5	< 5	< 5	< 5	< 5
	12	80	< 5	< 5	< 5	< 5	< 5
	14/16/20	320/320/160	N/A	N/A	N/A	N/A	N/A

Neutralizing antibody titers against the injected vector (AAVrh32.33) and cross-reactive neutralizing against other serotypes (AAV1, AAV2, AAV5, AAV8, and AAV9) monthly after vaccination of rhesus macaques.