Table 3.
Diagnostic criteria used for CAPA diagnosis and all cause mortality.
| Study | Study design | Diagnostic criteria | Proven | Probable | Putative | IAPA criteria | Colonization | Mortality |
|---|---|---|---|---|---|---|---|---|
| Machado et al. [36] | Prospective | EORTC/MSG modified AspICU | 0 | 8 | 0 | 0 | 9 | 8/8 |
| Koehler et al. [16] | Retrospective | Modified AspICU algorithm | 0 | 0 | 5 | 0 | 0 | 3/5 |
| Nasir et al. [26] | Retrospective | Modified AspICU algorithm | 0 | 0 | 5 | 0 | 4 | 3/5 |
| Alanio et al. [9] | Prospective | EORTC/MSG modified AspICU | 0 | 1 | 8 | 0 | 0 | 4/9 |
| Dupont et al. [61] | Prospective | Modified AspICU algorithm | 0 | 0 | 19 | 0 | 0 | 7/19 |
| Prattes et al. [19] | Case report | AspICU algorithm | 0 | 0 | 1 | 0 | 0 | 1/1 |
| Wang et al. [21] | Retrospective | EORTC/MSG | 0 | 8 | 0 | 0 | 0 | NA |
| Bruno et al. [64] | Case report | Modified AspICU algorithm | 0 | 0 | 1 | 0 | 0 | 0/1 |
| Meijer et al. [22] | Case report | Modified AspICU algorithm | 0 | 0 | 1 | 0 | 0 | 1/1 |
| Santana et al. [25] | Case report | Post-mortem histopathology | 1 | 0 | 0 | 0 | 0 | 1/1 |
| Borman et al. [35] | Retrospective | Modified AspICU algorithm | 0 | 0 | 15 | 0 | 0 | NA |
| Segrelles-Calvo et al. [51] | Prospective | EORTC/MSG | 0 | 7 | 0 | 0 | 0 | 5/7 |
| Patti et al. [54] | Case report | IAPA criteria | 0 | 0 | 0 | 1 | 0 | 0/1 |
| White et al. [32] | Prospective | AspICU algorithm, modified AspICU algorithm, CAPA criteria | 0 | 0 | 25 | 0 | 0 | 13/25 |
| Helleberg et al. [31] | Case series | AspICU algorithm | 0 | 0 | 2 | 0 | 0 | 2/2 |
| Trujillo et al. [65] | Case report | EORTC/MSG | 0 | 1 | 0 | 0 | 0 | 0/1 |
| Spadea et al. [66] | Case report | EORTC/MSG | 0 | 1 | 0 | 0 | 0 | 0/1 |
| Van Biesen et al. [28] | Cohort study | AspICU algorithm | 0 | 0 | 9 | 0 | 0 | 2/9 |
| Lamoth et al. [27] | Cohort study | Modified AspICU algorithm, IAPA criteria | 0 | 0 | 2 | 1 | 0 | 1/3 |
| Mitaka et al. [67] | Retrospective | AspICU algorithm | 0 | 0 | 4 | 0 | 3 | 4/4 |
| Nasri et al. [68] | Case report | EORTC/MSG | 0 | 1 | 0 | 0 | 0 | 1/1 |
| Gangneux et al. [33] | Prospective | AspICU algorithm, Modified AspICU algorithm | 0 | 0 | 7 | 0 | 8 | 2/7 |
| Roman-Montes et al. [58] | Prospective | Modified AspICU algorithm | 0 | 0 | 14 | 0 | 0 | 8/14 |
| Blaize et al. [18] | Case report | AspICU algorithm | 0 | 0 | 1 | 0 | 0 | 1/1 |
| Schein et al. [55] | Case report | EORTC/MSG | 0 | 1 | 0 | 0 | 0 | 1/1 |
| Fernandez et al. [69] | Case report | EORTC/MSG | 0 | 1 | 0 | 0 | 0 | 1/1 |
| Ghelfenstein-Ferreira et al. [24] | Case report | AspICU algorithm | 0 | 0 | 1 | 0 | 0 | 1/1 |
| Falces-Romero et al. [30] | Retrospective | EORTC/MSG, AspICU algorithm | 0 | 1 | 7 | 0 | 0 | 6/8 |
| Mohamed et al. [23] | Case report | AspICU algorithm | 0 | 0 | 1 | 0 | 0 | 1/1 |
| Antinori et al. [20] | Case report | EORTC/MSG post mortem | 1 | 0 | 0 | 0 | 0 | 1/1 |
| Lahmer et al. [34] | Case report | AspICU algorithm | 0 | 0 | 2 | 0 | 0 | 2/2 |
| Chauvet et al. [41] | Retrospective | EORTC/MSG, AspICU algorithm, Modified AspICU algorithm | 0 | 1 | 5 | 0 | 0 | 4/6 |
| Bartoletti et al. [8] | Prospective | IAPA criteria | 0 | 0 | 0 | 30 | 0 | 13/30 |
| van Arkel et al. [17] | Cohort study | IAPA criteria | 0 | 0 | 0 | 6 | 0 | 4/6 |
| Rutsaert et al. [10] | Case series | AspICU algorithm | 4 | 0 | 3 | 0 | 0 | 4/7 |
| Total | 6 | 31 | 138 | 38 | 24 | 105/190 (55%) |
Cases according to AspICU algorithm is 133, EORTC/MSG criteria is 37, IAPA criteria is 38, CAPA criteria is 5.
AspICU algorithm: A clinical algorithm to diagnose Invasive Pulmonary Aspergillosis in intensive care unit patients; CAPA: COVID-19-associated aspergillosis; EORTC/MSG: European Organization for Research and Treatment of Cancer/Mycoses Study Group; IAPA: Influenza-associated pulmonary aspergillosis; ICU: Intensive care unit.