Table 4. Base Case Deterministic Results per Cow’s Milk Tolerant or Symptom-free Child (discounted).
| Comparator | Total costs | Effects | Incremental costs | Incremental effects | ICER* | Net Monetary Benefit | |
|---|---|---|---|---|---|---|---|
| Probability of being symptom free at 3 years | WTP £2645 | WTP £7046 | |||||
| EHCF+LGG | £1859 | 0.703 | £0 | £3093 | |||
| SF | £1978 | 0.522 | £119 | -0.181 | dominated | -£598 | £1698 |
| EHWF | £2335 | 0.534 | £476 | -0.169 | dominated | -£923 | £1427 |
| AAF | £4505 | 0.639 | £2645 | -0.064 | dominated | -£2814 | £0 |
| Life years without symptoms at 3 years | WTP £765 | WTP £2709 | |||||
| EHCF+LGG | £1859 | 2.431 | £0 | £4922 | |||
| SF | £1978 | 1.704 | £119 | -0.727 | dominated | -£675 | £2776 |
| EHWF | £2335 | 1.725 | £476 | -0.705 | dominated | -£1016 | £2478 |
| AAF | £4505 | 1.615 | £2645 | -0.816 | dominated | -£3270 | £0 |
| Probability of cow’s milk tolerance at 3 years | WTP £2462 | WTP £25 088 | |||||
| EHCF+LGG | £1859 | 0.755 | £0 | £17 085 | |||
| SF | £1978 | 0.373 | £119 | -0.383 | dominated | -£1061 | £7367 |
| EHWF | £2335 | 0.397 | £476 | -0.358 | dominated | -£1358 | £7618 |
| AAF | £4505 | 0.180 | £2645 | -0.576 | dominated | -£4062 | £0 |
| Life years with cow’s milk tolerance at 3 years | WTP £1 042 | WTP £15 480 | |||||
| EHCF+LGG | £1859 | 1.785 | £0 | £25 766 | |||
| SF | £1978 | 0.734 | £119 | -1.051 | dominated | -£1214 | £9376 |
| EHWF | £4505 | 0.895 | £476 | -0.889 | dominated | -£1403 | £11 522 |
| AAF | £2954 | 0.291 | £2645 | -1.494 | dominated | -£4201 | £0 |
* Calculated as the difference in costs divided by the difference in effects.
Abbreviations: AAF, amino acid-based formula; EHCF+LGG, extensively hydrolysed casein formula containing Lactobacillus rhamnosus Gorbach Goldin; EHWF, extensively hydrolysed whey formula; ICER, incremental cost-effectiveness ratio; SF, soy formula; WTP, willingness to pay threshold.