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. 2021 Jul 1;53(8):1187–1195. doi: 10.1038/s41588-021-00891-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 10 — a, Genome-wide map of all de novo CNA events that were observed in eight PDTO-9 and four PDTO-19b datasets (respectively, 310 and 158 analysed single cells), and 64 PDTO-9 cell divisions (128 analysed single cells). Events include reciprocal CNAs, non-reciprocal whole-chromosome gains or losses and non-reciprocal sub-chromosomal CNAs represented in more than one cell. Hopeful monster karyotypes were excluded for this representation. Centromeric and other complex regions of chromosomes are depicted in red. b, Metaphase spread-based karyotyping of 36 tumor cells from PDTO-9 and PDTO-19b stained with DAPI to confirm their near-diploid genome. Each dot represents a tumor cell, center bar and error bars represent the mean and standard deviation. Scalebar is 5 μm.