Table 2.
Sertraline and desmethylsertraline plasma concentrations
| N | Dose (mg) |
Measured concentration (ng/mL) |
Dose-adjusted concentration (ng/mL)/(mg/day) | |||
|---|---|---|---|---|---|---|
| Median (range) | Median (Q1–Q3) | Range | Median (Q1–Q3) | Range | ||
| Sertraline | ||||||
| 2nd trimester | 7 | 50 (50–50) | 7.65 (5.81–12.09) | 3.98–17.14 | 0.15 (0.12–0.24) | 0.08–0.34 |
| 3rd trimester | 9 | 50 (50–75) | 9.49 (7.34–17.14) | 1.53–20.81 | 0.19 (0.12–0.23) | 0.03–0.38 |
| At delivery | 8 | 75 (50–100) | 14.38 (7.65–18.67) | 3.64–24.17 | 0.19 (0.15–0.25) | 0.07–0.32 |
| Postpartum | 8 | 75 (50–75) | 17.9 (8.87–19.35) | 6.12–52.02 | 0.25 (0.17–0.29) | 0.12–0.69 |
| Desmethylsertraline | ||||||
| 2nd trimester | 7 | 50 (50–50) | 24.25 (22.65–32.29) | 15.78–10.52 | 0.49 (0.45–0.65) | 0.32–0.88 |
| 3rd trimester | 9 | 50 (50–75) | 35.06 (28.05–55.52) | 10.52–61.36 | 0.70 (0.47–0.74) | 0.21–1.11 |
| At delivery | 8 | 75 (50–100) | 33.60 (22.95–46.75) | 7.01–61.36 | 0.46 (0.37–0.62) | 0.14–0.82 |
| Postpartum | 6 | 75 (50–75) | 45.29 (28.56–78.89) | 16.95–87.66 | 0.69 (0.43–1.05) | 0.34–1.17 |
Sertraline dose presented as median and range (min-max) and measured and dose-adjusted sertraline and desmethylsertraline plasma concentrations presented as medians, interquartile ranges (Q1–Q3) and ranges (min-max)