Table 3.
Changes in collagen content using a log linear mixed effects model for estimated ratio of intensity density of collagen by treatment and control group
| Group | Intensity density± of collagen ratio | p-value* | [95% conf. interval] | p-value for interaction | |
|---|---|---|---|---|---|
| G1 | 0.514 | <0.001 | 0.383 | 0.690 | - |
| G2/D1 | 0.419 | 0.004 | 0.233 | 0.756 | 0.545 |
| G2/D2 | 0.784 | <0.001 | 0.732 | 0.840 | 0.006 |
| G2/D3 | 0.533 | <0.001 | 0.435 | 0.653 | 0.839 |
G1=Group 1; G2/D1=Group 2 Dose 1; G2/D2=Group 2 Dose 2; G2/D3=Group 2 Dose 3
± Intensity density is the sum of pixel values for collagen from ImageJ software analysis
Controls consisted of adjacent fibroids from the same subject. * Indicates a statistically significant change in collagen intensity density between treatment and control, p-value < 0.001
**Indicates a statistically significant difference in change in collagen intensity density between treatment and control for group2/D2 vs. group 1