. 2021 Aug 6;11:16021. doi: 10.1038/s41598-021-95638-8

Table 3.

dAI-ACC WM tract microstructural feature association with cognitive and affective measures in PD.

	FA of left dAI to ACC	FA of right dAI to ACC	MD of left dAI to ACC	MD of right dAI to ACC
CAMCOG
r_s	0.135	0.007	− 0.277	− 0.267
p-value	0.350	0.959	0.054	0.056
N	50	53	49	52
Fluency
r_s	0.137	− 0.057	− 0.314*	− 0.280*
p-value	0.341	0.687	0.028	0.044
N	50	53	49	52
PRM
r_s	− 0.160	− 0.182	− 0.107	− 0.007
p-value	0.271	0.196	0.468	0.963
N	49	52	48	51
SSP
r_s	0.168	0.184	− 0.304*	− 0.285*
p-value	0.249	0.192	0.036	0.042
N	49	52	48	51
SWM
r_s	− 0.144	− 0.083	0.329*	0.429**
p-value	0.324	0.556	0.022	0.002
N	49	52	48	51
IED
r_s	0.027	0.164	− 0.144	− 0.129
p-value	0.858	0.252	0.335	0.371
N	48	51	47	50
VPT
r_s	− 0.014	− 0.060	0.089	0.104
p-value	0.925	0.671	0.548	0.468
N	49	52	48	51
BDI
r_s	− 0.212	− 0.110	0.214	0.263
p-value	0.144	0.436	0.143	0.062
N	49	52	48	51
BAI
r_s	− 0.298	0.014	0.392*	0.289
p-value	0.104	0.940	0.032	0.121
N	31	31	30	30

r_s = Spearman correlation; vAI = ventral anterior insula; dAI = dorsal anterior insula. CAMCOG = CAMbridge COGnitive examination revised test battery; PRM = pattern recognition memory; SSP = spatial span; SWM = spatial working memory; IED = the intra-extra dimensional set shift test; VPT = Vienna perseveration test; BAI = Beck Anxiety Inventory; BDI = the Beck Depression Inventory. *p < 0.05, **p < 0.01.