Fig. 1. Intestinal FGF15 expression increases and prevents muscle mass loss after VSG in mice.
a FGF15 RNA expression in duodenum, jejunum and ileum in control Sham and VSG mice fed 60% HFD. Intestinal mucosa was collected 15 min post mixed meal gavage (n = 6 Sham and 7 VSG). b Experimental timeline. c Body weight and d food intake before surgery. e Body weight after surgery. f Fat body mass and g lean body mass before and after surgery. h Cumulative food intake and i energy efficiency for weeks 1–8 after surgery. j Food intake, k fecal energy and l absorbed energy during week 11 after surgery. Animal number: Control Sham (n = 6), Control VSG (n = 8), FGF15INT-KO Sham (n = 8), FGF15INT-KO VSG (n = 5). Data are shown as means ± SEM. Panels a, c, and d were analyzed with Student’s two-tailed t test. Panels e–l were analyzed with two-way ANOVA with Tukey’s post hoc test. *p < 0.05.