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. 2021 Aug 6;12:4768. doi: 10.1038/s41467-021-24914-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a 3D images of trabecular bone, scale bars 500 μm. b Trabecular bone volume fraction (Tb. BV/TV), c trabecular bone mineral density (Tb. BMD), d trabecular bone connective density (Conn. Des) and e trabecular number (Tb. N), f thickness of the trabecular bone (Tb. Th), g spacing between trabeculae (Tb. Sp). h 3D images of mid-cortical bone, scale bars 500 μm. i Thickness of the cortical bone (Ct. Th). j Cortical bone area (Ct. BA/TA) and k cortical bone mineral density (Ct. BMD). l Tibial BMAT was visualized by osmium staining. m, n Representative sections from proximal and distal tibiae were stained with H&E and are shown at ×100 magnification, scale bars 200 μm. l Tibial BMAT was quantified relative to total bone volume after osmium staining within the indicated regions as shown in (o) proximal Tibia (①-②), p growth plate (G/P) to tibia/fibula junction (T/F J) (①-③), q distal tibia is T/F J to distal end (③-④). Animal number: Control Sham (n = 5), Control VSG (n = 8), FGF15^INT-KO Sham (n = 7), FGF15^INT-KO VSG (n = 5). Data are shown as means ± SEM. *p < 0.05 (two-way ANOVA with Tukey’s post hoc test).