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. 2021 Aug 6;12:4768. doi: 10.1038/s41467-021-24914-y

Fig. 3. Loss of intestinal FGF15 increases circulating fibroblast growth factor 23 (FGF23) and erythropoietin (EPO) levels after VSG.

Fig. 3

Plasma levels of a FGF23, b phosphate, c 25(OH) vitamin D, d erythropoietin, e hemoglobin and f ferritin. g Heart to body weight ratio. h H&E stain of liver sections, CV = central vein, PV = portal vein, Zones 1–3, scale bars 100 μm. i RNA expression of Dmt1, Dcytb, Hamp, Slc401a1 (Fpn) and Hif2α in duodenum. j Iron levels in cecal contents. Animal number for (a–f) and (i, j): Control Sham (n = 5), Control VSG (n = 8), FGF15INT-KO Sham (n = 8), FGF15INT-KO VSG (n = 5). Animal number for g: Control Sham (n = 6), Control VSG (n = 8), FGF15INT-KO Sham (n = 8), FGF15INT-KO VSG (n = 5). Data are shown as means ± SEM. *p < 0.05 (two-way ANOVA with Tukey’s post hoc test).