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. 2021 Aug 6;11:16036. doi: 10.1038/s41598-021-95396-7

Table 2.

Human (Homo sapiens) and horse (Equus caballus) α-synuclein (α-syn) amino acid sequences. The 140 amino acid α-syn protein consists of three regions: N-terminal amphipathic region (residues 1 to 60), hydrophobic non-amyloid-β component (NAC) (residues 61–95) and the acidic C-terminal region (residues 96–140). Tango bioinformatic aggregation scores (35–37) of the full-length human and equine α-syn are 896 and 1042, respectively. Aggregation scores for each segment of the human and equine α-syn.

Fragment 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Variation Agg score
Human M D V F M K G L S K A K E G V V A A A E K T K Q G 57
Horse M D V F M K G L S K A K E G V V A A A E K T K Q G 0 57
Fragment 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50
Human V A E A A G K T K E G V L Y V G S K T K E G V V H 291
Horse V A E A A G K T K E G V L Y V G S K T K E G V V H 0 291
Fragment 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75
Human G V A T V A E K T K E Q V T N V G G A V V T G V T 117
Horse G V T T V A E K T K E Q V T N V G E A V V T G V T 2 56
Fragment 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100
Human A V A Q K T V E G A G S I A A A T G F V K K D Q L 5
Horse A V A Q K T V E G A E S I A A A T G F G K K D H L 3 8
Fragment 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61
Human V L Y V G S K T K E G V V H G V A T V A E K T K E 53
Horse V L Y V G S K T K E G V V H G V T T V A E K T K E 1 39
Fragment 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86
Human Q V T N V G G A V V T G V T A V A Q K T V E G A G 483
Horse Q V T N V G E A V V T G V T A V A Q K T V E G A E 2 637
Fragment 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115
Human A T G F V K K D Q L G K N E E G A P Q E G I L E D 0
Horse A T G F G K K D H L G K S E E G A A Q E G I L E D 4 0
Fragment 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140
Human M P V D P D N E A Y E M P S E E G Y Q D Y E P E A 0
Horse M P V D P D N E A Y E M P S E E G Y Q D Y E P E A 0 0

Peptide are provided in the right-sided column.