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. 2021 Aug 6;12(8):776. doi: 10.1038/s41419-021-04030-x

Fig. 1. Hypoxic stress leads to inflammation in lung cancer.

Fig. 1

A Gene enrichment analysis on differentially expressed genes between LUSC tumors with low and high expression of HIF1α. B The groups of enriched genes in each pathway. C The heatmap of expression correlation of HIF1α with the genes in the cytokine-cytokine receptor interaction pathway. D The expression correlation of HIF1α and IL1A and IL6 from TCGA database (https://xena.ucsc.edu/welcome-to-ucsc-xena/). E, F The serum levels of IL1A (E) and IL6 (F) in lung cancer patients with low and high HIF1α expression in primary tumors (n = 8 in each group). G Flow cytometry analysis of macrophages in human lung tumors with low and high HIF1α expression. Representative images are shown. H The immunofluorescence staining of CD68 and CA9 in human lung tumors with low and high HIF1α expression. Scale bar, 20 μm. * p < 0.05; ** p < 0.01.