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. 2021 Aug 6;12(8):776. doi: 10.1038/s41419-021-04030-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A The expression of miRNAs in A549 cells under normoxia and hypoxia. B The expression of miR101, miR30, and miR486, miR3927 in the exosomes of A549 cells treated with CoCl₂. C The miR101 expression in human lung tumors with low and high HIF1α expression. D The miR101 expression in the blood of patients with lung cancer with low and high HIF1α expression in tumors. E The correlation between miR101 and HIF1α expression in the LUSC database. F The miR101 expression in lung adjacent and tumor samples from the GEO database (GSE15008). G A549 cells transfected with pcdna6.2-gw/emgfp miR101 were treated with CoCl₂ for 1 d. The mRNA level of miR101 in the A549 cells and exosome was analyzed. H, I A549 cells transfected with pcdna6.2-gw/emgfp miR101 were treated with CoCl₂ for 1 d, and co-cultured with THP-1 cells. (H) The expression of IL1A and IL6 in A549 and THP-1 cells was analyzed by RT-PCR. I The growth of A549 was analyzed by BrdU assay. ^# p > 0.05; * p < 0.05; ** p < 0.01; *** p < 0.001.