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. 2021 Aug 6;12:4776. doi: 10.1038/s41467-021-24958-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Genome-wide integrated haplotype scores (iHS) within the Mayuge population (n = 181) a region of long-term MDA pressure (8–9 previous annual rounds). b Genome-wide integrated haplotype scores (iHS) within the Tororo populations (n = 17), a region of short-term MDA pressure (1 previous round with limited coverage). Points represent median values of all variants in 2 kb non-overlapping windows along the eight S. mansoni chromosomes (shown in alternating shades of grey). c Genome-wide cross-population extended haplotype heterozygosity values (XP-EHH) between populations from Mayuge district and Tororo district, calculated as the median of all variants in 2 kb non-overlapping windows. d Fixation index (F_ST) values between populations from Mayuge district and Tororo district, calculated as the mean of F_ST scores in non-overlapping 2 kb windows. e Nucleotide diversity was calculated as the mean of 2 kb windows across each chromosome for each district, the ratio between Mayuge and Tororo 2 kb windows is shown. Windows with the highest 0.25% of values in the Mayuge iHS, F_ST and XP-EHH statistics (shown as red points) were used to define candidate regions of selection. Windows with a 300 kb of each other were joined into continuous regions of selection, any of those regions with <8 windows with elevated values across any statistic were discarded (Supplementary Data 4).