Table 2.
Univariate and Multivariate Cox proportional hazards analysis for DFS on RM/clinicopathological variables/Odx risk category on St and St.
| Clinicopathological Variables | TCGA BRCA Hazard Ratio (p, 95% Confidential Interval), patient number |
ECOG 2197 Hazard Ratio (p, 95% Confidential Interval), patient number |
|---|---|---|
| Univariate analysis | ||
|
Lymph node (node+ vs. node−) |
HR = 0.85 (p = 0.69, CI = 0.37–1.9), N = 59 | HR = 2.15 (p = 0.0042, CI = 1.27–3.6), N = 219 |
|
PR (PR+ vs. PR−) |
HR = 1.17 (p = 0.73, CI = 0.48–2.9), N = 78 | HR = 0.71 (p = 0.39, CI = 0.32–1.6), N = 219 |
|
HER2 (HER2+ vs. HER2−) |
HR = 0.95 (p = 0.93, CI = 0.33–2.7), N = 48 | HR = 1.25 (p = 0.57, CI = 0.58–2.7), N = 128 |
|
Tumor grade (grade 3 vs. grade 2 vs. grade 1) |
Variable not available | HR = 0.88 (p = 0.54, CI = 0.59–1.3), N = 195 |
|
Tumor size (≥2 cm vs. <2 cm) |
HR = 1.27 (p = 0.6, CI = 0.52–3.1), N = 78 | HR = 1.5 (p = 0.13, CI = 0.88–2.5), N = 217 |
|
Age (≥50 years vs. <50 years) |
HR = 1.06 (p = 0.87, CI = 0.51–2.2), N = 77 | HR = 1.17 (p = 0.54, CI = 0.7–2), N = 219 |
|
Oncotype Dx category (high vs. intermediate vs. low) |
Variable not available | HR = 1.61 (p = 0.09, CI = 0.93–2.8), N = 59 |
|
Race (non-caucasian vs. caucasian) |
HR = 1.14 (p = 0.79, CI = 0.43–3), N = 73 | HR = 0.71 (p = 0.5, CI = 0.26–1.9), N = 219 |
|
Histology type (lobular invasive carcinoma vs. ductal invasive carcinoma) |
HR = 0.21 (p = 0.13, CI = 0.03–1.6), N = 71 | Variable not available |
|
Model-derived risk category (RMH vs. RML) |
HR = 3.49 (p = 0.001, CI = 1.6–7.6), N = 78 | HR = 2.67 (p = 2.28e−04, CI = 1.58–4.5), N = 219 |
| Multivariate analysis | ||
| Clinicopathological Variables | TCGA BRCA (N = 47) | ECOG 2197 (N = 193) |
|
Lymph node (node+ vs. node−) |
HR = 0.35 (p = 0.1, CI = 0.1–1.2) | HR = 2.75 (p = 0.001, CI = 1.49–5.1) |
|
PR (PR+ vs. PR−) |
HR = 9.26 (p = 0.01, CI = 1.72–50) | HR = 0.82 (p = 0.63, CI = 0.36–1.9) |
|
Tumor grade (grade 3 vs. grade 2 vs. grade 1) |
Variable not available | HR = 1.02 (p = 0.93, CI = 0.66–1.6) |
|
Tumor size (≥2 cm vs. <2 cm) |
HR = 1.01 (p = 0.99, CI = 0.28–3.6) | HR = 1.57 (p = 0.12, CI = 0.89–2.8) |
|
Age (≥50 years vs. <50 years) |
HR = 1.04 (p = 0.95, CI = 0.35–3) | HR = 1.02 (p = 0.93, CI = 0.58–1.8) |
|
Race (non-caucasian vs. caucasian) |
HR = 1.75 (p = 0.48, CI = 0.37–8.3) | HR = 1.51 (p = 0.44, CI = 0.53–4.3) |
|
Histology type (lobular invasive carcinoma vs. ductal invasive carcinoma) |
HR = 0 (p = 0.99, CI = 0~ Inf) | Variable not available |
|
Model-derived risk category (RMH vs. RML) |
HR = 3.45 (p = 0.04, CI = 1.03–12) | HR = 3.82 (p = 5.79e–06, CI = 2.14–6.8) |
The latter subgroup for each variable (e.g. node -) was used as the reference category for HR calculation