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. 2021 Aug 6;11:15989. doi: 10.1038/s41598-021-95059-7

Figure 5.

Figure 5

Effect of CSF1R inhibition and cocaine administration on neurotrophic levels and TrkB mRNA expression in the brain. Quantification of BDNF in the striatum [cocaine factor (F(1,21) = 0.27; p = 0.6058), CSF1R inhibition factor (F(1,21) = 1.15; p = 0.2946) and cocaine vs CSF1R inhibition factor (F(1,21) = 2.17; p = 0.1555) (A), in the hippocampus [cocaine factor (F(1,21) = 97.38; p < 0.0001), CSF1R inhibition factor (F(1,21) = 41.00; p < 0,0001) and cocaine vs CSF1R inhibition factor (F(1,21) = 3.22; p = 0.0868)] (B) and in the PFC [cocaine factor (F(1,20) = 3.81; p = 0.0650), CSF1R inhibition factor (F(1,20) = 0.37; p = 0.5455) and cocaine vs CSF1R inhibition factor (F(1,20) = 0.48; p = 0.4937)] (C). Quantification of TrkB mRNA expression in the striatum [cocaine factor (F(1,23) = 0.93; p = 0.34), CSF1R inhibition factor (F(1,23) = 0.75; p = 0.3940) and cocaine vs CSF1R inhibition factor (F(1,23) = 1.41; p = 0.2458)] (D), hippocampus [cocaine factor (F(1,23) = 0.51; p = 0.4797), CSF1R inhibition factor (F(1,23) = 0.10; p = 0.7518) and cocaine vs CSF1R inhibition factor (F(1,23) = 0.003; p = 0.9541)]. (E) and PFC [cocaine factor (F(1,23) = 0.62; p = 0.4371), CSF1R inhibition factor (F(1,23) = 5.52; p = 0.0265) and cocaine vs CSF1R inhibition factor (F(1,23) = 4.04; p = 0.0563)] (F). Results are expressed as mean ± SEM. #p < 0.05, ##p < 0.01 and ####p < 0.0001 difference between the saline and cocaine groups. *p < 0.05 and ****p < 0.0001 compared with the PLX3397 treated group (n = 4–7 in each group).