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. 2021 Aug 6;12:4753. doi: 10.1038/s41467-021-25012-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Overall study design. b The TMB distribution of BilIN-related gallbladder carcinoma (GBC) in the context of stage-I samples from 16 TCGA cancer types. c Relative contributions of different mutational signatures (annotated by etiology factors) in GBC and 16 TCGA cancer types. b, c GBC is highlighted in the red box. READ: rectum adenocarcinoma; THCA: thyroid carcinoma; TGCT: testicular germ cell tumors; KICH: kidney chromophobe; BRCA: breast invasive carcinoma; CHOL: cholangiocarcinoma; PAAD: pancreatic adenocarcinoma; KIRC: kidney renal cell carcinoma; KIRP: kidney renal papillary cell carcinoma; LIHC: liver hepatocellular carcinoma; HNSC: head and neck squamous cell carcinoma; ESCA: esophageal carcinoma; COAD: colon adenocarcinoma; STAD: stomach adenocarcinoma; LUAD: lung adenocarcinoma; LUSC: lung squamous cell carcinoma.