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. 2021 Aug 6;12:4753. doi: 10.1038/s41467-021-25012-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a LOH percentage in GBC samples (BilIN-independent: n = 6; BilIN-dependent: n = 5). b LOH percentage in BilIN samples (BilIN-independent: n = 6; BilIN-dependent: n = 5). c LOH percentage shared by GBC, LG-BilIN, and HG-BilIN (BilIN-independent: n = 6; BilIN-dependent: n = 5). d Chromosome-level LOH shared by GBC, LG-BilIN, and HG-BilIN samples (BilIN-independent: n = 6; BilIN-dependent: n = 5). e A heatmap showing sample clustering patterns based on chromosome-wide LOH status. f The number of clones and g the number of mutation loci used in the clonal evolution analysis. The middle line in the box is the median, the bottom, and top of the box are the first and third quartiles, and the whiskers extend to 1.5× interquartile range of the lower and the upper quartiles, respectively. Raw p-values based on the two-tailed Student’s t-test are shown.