Table 2:

Results of Age AccelerationResidual and additional predictors on regional brain characteristics in PHIV

Sample	Structural measure	Brain region	Hem.	Sex β(p)	Age β(p)	CPE β(p)	Age acceleration β(p)	R^2	P
HIV infected
	Thickness	Pars opercularis	R	.14(.047)		−.14(.060)	.16(.031)	.069	.006
		Insula	L	.15(.044)		−.15(.046)		.042	.022
		Precentral gyrus	L	.171(.022)			.15(.049)	.046	.016
	Area	Inf temporal gyrus	L	−.24(.001)		.14(.052)	.20(.007)	.115	<.001
		Sup temporal gyrus	L	−.16(.033)			.20(.008)	.135	<.001
		Inf temporal gyrus	R	−.14(.053)		.15(.040)	.09(.013)	.071	.005
		Lateral occipital gyrus	L	−.27(.000)		.14(.060)	.15(.043)	.110	<.001
		Lat orbitofrontal gyrus	L	−.24(.001)			.17(.017)	.094	<.001
		Transverse temporal gyrus	R	−.25(.001)		.14(.065)	.17(.020)	.105	<.001
		Caudal middle frontal	L	−.25(.000)			.26(.000)	.140	<.001
		Caudal anterior cingulate	L	−.15(.052)			.14(.067)	.043	.020
		Paracentral gyrus	L	−.32(<.001)			.17(.018)	.142	<.001
		Pars orbitalis	L	−.27(<.001)			.29(<.001)	.172	<.001
		Posterior cingulate	L	−.25(<.001)			.20(.005)	.116	<.001
		Precentral gyrus	L	−.29(<.001)			.22(.002)	.144	<.001
		Rostral anterior cingulate	L	−.24(.001)			.16(.024)	.093	<.001
		Rostral middle frontal gyrus	L	−.23(.001)			.27(<.001)	.135	<.001
		White matter surface area	L	−.26(.001)			.18(.011)	.111	<.001
		Caudal middle frontal	R	−.23(.002)			.17(.020)	.088	<.001
		Inf parietal gyrus	R	−.25(.001)			.17(.017)	.012	<.001
		Paracentral	R	−.24(.001)			.24(<.001)	.126	<.001
		Pars orbitalis	R				.28(.001)	.080	<.001
		Pars triangularis	R	−.21(.003)			.25(.001)	.116	<.001
		Precentral	R	−.20(.007)			.21(.004)	.091	<.001
		Rostral middle frontal	R	−.16(.027)			.30(<.001)	.123	<.001
		Sup frontal	R	−.22(.002)			.21(.004)	.102	<.001
		Insula	R	−.29(<.001)			.16(.027)	.120	<.001
		White matter surface area	R	−.19(.008)			.19(.010)	.081	<.001
	Volume	Amygdala	R	−.22(.003)			.15(.038)	.076	.001
		Total gray matter volume	L+R	−.22(.003)			.14(.049)	.077	<.001
		Brain stem	n/a	−.15(.040)	−.20(.006)
	FA	Retrolenticular part of the internal capsule	L	.18(.043)			.17(.058)	.071	.030
		External capsule	R				.23(.009)	.055	.009
		External capsule	L				.22(.012)	.050	.012
	MD	Superior Corona radiata	R			−.21(.019)		.044	.019
		Sup fronto occipital fasciculus	L			−.35(<.001)		.126	<.001
		Sup cerebellar peduncle	R	−.19(.033)				.037	.033
	AD	Sup cerebellar peduncle	R	−.24(.008)				.056	.008
		Sup corona radiata	R			−.21(.022)		.042	.022

Standardized beta scores (β) for each predictor variable in each model are shown in the relevant named columns, with p values in parentheses. R^2 values and p values in the final column are for each full model. Each row is one full model. Included covariates that are significant predictors (p<0.05) in each model are highlighted in bold.