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. Author manuscript; available in PMC: 2021 Aug 27.
Published in final edited form as: Hepatology. 2021 Aug 10;74(2):667–685. doi: 10.1002/hep.31743

Figure 1. Progression and regression of fibrosis in foz/foz mice.

Figure 1.

Six weeks old foz/foz mice were fed either standard chow (0w) or WD for 12 weeks (12w) or subjected to regression by switching 12w WD fed mice to standard chow for 8 additional weeks. Representative images of liver histology depicting steatosis (a; hematoxylin-eosin (H&E) staining) and fibrosis (b; sirius red staining; quantified as sirius red positive area normalized to non-steatotic area); Scale bar: 100 μm. (c) Total RNA was extracted from the liver lysates and expression of indicated fibrogenic markers were analyzed by qPCR. The data is represented as fold induction versus foz/foz mice on standard chow (0w WD group). All bar graphs represent mean ± SEM, *p <0.05, **p <0.01, ***p <0.001, ****p <0.0001 by ANOVA.