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. 2021 Aug 6;12:4740. doi: 10.1038/s41467-021-24979-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Spearman’s rank correlation test between levels (median fluorescence intensity, MFI) of IgA, IgG, and IgM against each antigen (Nucleocapsid full-length protein (N), and its C-terminal domain, the Receptor Binding Domain (RBD), full S protein and its subregions S1 and S2) at A baseline visit (M0) and B M6 visit; and plasma neutralization capacity (as a percentage of RBD-ACE2 binding inhibition). Two-sided spearman test was used to calculate the p-values and r_s correlation coefficients are color-coded for each antigen/isotype pair. Colored lines represent the fitted curve calculated using the linear model method. Shaded areas represent 95% confidence intervals.