Table 4.
Parameter | Treadmill speed (cm/s) | Control mean | Control SD | Hb9-vGluT2OFF mean | Hb9-vGluT2OFF SD | F (DFn, DFd) speed | F (DFn, DFd) genotype | F (DFn, DFd) interaction | P value speed | P value genotype | P value interaction |
---|---|---|---|---|---|---|---|---|---|---|---|
Stride length average (mm) | F (3, 52) = 130.7 | F (1, 21) = 0.01024 | F (3, 52) = 0.7065 | < 0.0001 | 0.9204 | 0.5525 | |||||
15 | 44.79 | 4.12 | 44.99 | 3.81 | |||||||
20 | 49.12 | 4.61 | 48.69 | 4.98 | |||||||
27 | 55.50 | 4.54 | 55.11 | 4.26 | |||||||
30 | 57.23 | 5.84 | 58.01 | 2.36 | |||||||
Stride length variability | F (3, 52) = 20.27 | F (1, 21) = 0.5751 | F (3, 52) = 2.626 | < 0.0001 | 0.4567 | 0.0601 | |||||
15 | 0.21 | 0.04 | 0.20 | 0.04 | |||||||
20 | 0.15 | 0.03 | 0.18 | 0.07 | |||||||
27 | 0.12 | 0.03 | 0.15 | 0.04 | |||||||
30 | 0.14 | 0.04 | 0.13 | 0.04 | |||||||
Cycle duration average (ms) | F (3, 52) = 182.4 | F (1, 21) = 0.09977 | F (3, 52) = 1.081 | < 0.0001 | 0.7552 | 0.3655 | |||||
15 | 294.87 | 20.79 | 297.98 | 29.64 | |||||||
20 | 257.04 | 25.87 | 248.73 | 24.04 | |||||||
27 | 220.39 | 20.30 | 215.98 | 19.45 | |||||||
30 | 205.34 | 22.49 | 209.13 | 11.22 | |||||||
Cycle duration variability | F (3, 52) = 6.127 | F (1, 21) = 0.3337 | F (3, 52) = 0.6572 | 0.0012 | 0.5696 | 0.5821 | |||||
15 | 0.17 | 0.04 | 0.15 | 0.05 | |||||||
20 | 0.14 | 0.03 | 0.15 | 0.04 | |||||||
27 | 0.12 | 0.03 | 0.12 | 0.03 | |||||||
30 | 0.13 | 0.06 | 0.11 | 0.03 | |||||||
Stance duration average (ms) | F (3, 52) = 353.8 | F (1, 21) = 0.0004317 | F (3, 52) = 0.7049 | < 0.0001 | 0.9836 | 0.5534 | |||||
15 | 200.68 | 11.21 | 205.02 | 19.54 | |||||||
20 | 161.32 | 14.96 | 158.74 | 17.74 | |||||||
27 | 126.88 | 10.68 | 125.83 | 15.84 | |||||||
30 | 115.41 | 9.98 | 119.13 | 8.78 | |||||||
Stance duration variability | F (3, 52) = 1.090 | F (1, 21) = 0.3011 | F (3, 52) = 2.060 | 0.3614 | 0.589 | 0.1168 | |||||
15 | 0.22 | 0.05 | 0.20 | 0.06 | |||||||
20 | 0.20 | 0.05 | 0.21 | 0.06 | |||||||
27 | 0.20 | 0.05 | 0.22 | 0.03 | |||||||
30 | 0.18 | 0.02 | 0.20 | 0.05 | |||||||
Swing duration average (ms) | F (3, 52) = 0.8343 | F (1, 21) = 0.001461 | F (3, 52) = 0.7162 | 0.4812 | 0.9699 | 0.5468 | |||||
15 | 90.23 | 14.06 | 92.96 | 12.53 | |||||||
20 | 91.64 | 19.05 | 89.99 | 10.58 | |||||||
27 | 90.61 | 14.92 | 90.15 | 7.49 | |||||||
30 | 87.16 | 15.34 | 90.00 | 6.57 | |||||||
Swing duration variability | F (3, 52) = 6.890 | F (1, 21) = 0.1320 | F (3, 52) = 1.647 | 0.0005 | 0.72 | 0.1898 | |||||
15 | 0.25 | 0.04 | 0.25 | 0.04 | |||||||
20 | 0.22 | 0.04 | 0.25 | 0.07 | |||||||
27 | 0.19 | 0.04 | 0.18 | 0.04 | |||||||
30 | 0.23 | 0.14 | 0.17 | 0.04 |
Repeated measures two way ANOVA. Bold indicates significant P values. See “Methods” for details.