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. 2021 May 28;12(3):873–889. doi: 10.1016/j.jcmgh.2021.05.014

Figure 1.

Figure 1

PRC2 members are expressed in M cells. (A) RT-qPCR analyses of the expression of Suz12 and Ezh2 in mouse intestinal organoids grown in ENR, ENR+RankL, and ENRI conditions. (B) Immunoblot of H3K27me3 and H3 in organoids treated with Ezh2 inhibitor (EI1) inhibitor. Data are representative of 2 independent experiments. (C) RT-qPCR analyses of the expression of M-cell marker genes in RankL-treated organoids with or without EZH2 inhibitor EI1. An unpaired 2-tailed Student t test was performed. ∗P < .05, ∗∗P < .01, and ∗∗∗P < .005, N = 3 independent experiments. Values are presented as means ± SD. Gapdh, glyceraldehyde-3-phosphate dehydrogenase; mRNA, messenger RNA.