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. 2021 May 28;12(3):873–889. doi: 10.1016/j.jcmgh.2021.05.014

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Esrrg expression is induced by RelB/p52 activation. (A) Ltα1β2 prominently up-regulated the expression of Esrrg in organoids. Organoids from C57BL/6JRj mice were stimulated with LTα1β2 for 3 days, and the gene expression was analyzed by qPCR. (B) Organoids from wild-type mice were stimulated with RankL for 3 days in the absence or presence of 125 μmol/L SC-514. Gene expression was analyzed by qPCR. (C) Organoids were transduced to express classic and noncanonical NF-κB and the expression of Esrrg and Spi-B (control) are represented relative to glyceraldehyde-3-phosphate dehydrogenase (Gapdh). (D) Organoids expressing p52 and RelB in the presence of SC-514 for 3 days, and the expression of Esrrg and Spi-B was analyzed by qPCR. Values in all are presented as the means ± SD and an unpaired 2-tailed Student t test was performed, N = 3 independent experiments. ∗P < .05, ∗∗P < .01, ∗∗∗P < .005. Ctrl, control; DMSO, dimethyl sulfoxide.