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PRC2 regulates the differentiation of M cells. In the absence of Rank–RankL signaling, Esrrg and Sox8 genes are repressed by PRC2 in the intestinal epithelium. When migrating progenitors with Rank receptors bind to RankL in PPs, this induces NF-κB signaling, leading to loss of H3K27me3 from the gene promoters and activation of Esrrg and Sox8. Sustained expression of Sox8 and GP2 and differentiation of M cells is dependent on Esrrg. ISC, intestinal stem cells.
