Fig. 4.

Statistical parametric maps from R1. Statistical parametric maps of the hypoperfusion patterns obtained from R1 (0–10 min) images in the Aβ⁺MCI group compared with the Aβ⁻NC group (A: uncorrected p < 0.001, t > 3.31) and in the Aβ⁺AD group compared with the Aβ⁺MCI group (B: FDR-corrected p < 0.05, t > 2.21). The arrow on the map of Aβ⁻NC > Aβ⁺ MCI indicates the area of perfusion reduction in the precuneus of the parietal cortex. Abbreviations: Aβ⁻NC, Aβ-negative normal cognition; Aβ⁺MCI, Aβ-positive mild cognitive impairment; Aβ⁺AD, Aβ-positive Alzheimer’s disease with dementia