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. 2021 Jun 14;5(4):pkab056. doi: 10.1093/jncics/pkab056

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© The Author(s) 2021. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Associations between smoking pack-years and risk of CRC subtypes defined by combined marker status. Two-sided Wald test was used to calculate the P values from the case-control analysis (N control = 10 199) and case-only analysis (P_difference). A Bonferroni corrected P value threshold of .005 was used for both case-control and case-only analyses. Error bars represent the 95% confidence intervals (CIs). CIMP = CpG island methylation phenotype; CRC = colorectal cancer; MSI = microsatellite instability; MSS = microsatellite stable; mut = mutated; OR = odds ratio; wt = wild type.