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Vancomycin penetration of biofilms depending on PIA or Embp CLSM showing vancomycin binding in the bottom layer of the biofilms formed by S. epidermidis 1585, 1585Pxyl/tetembp, 1585pTXicaADBC and 1585Δembp in TSB, BHI, BHI with 50 % (v/v) human plasma. Blue, intracellular DNA; red, extracellular DNA; green, BodipyFL vancomycin.
