Table 3.
Related resistance determinants of tigecycline non-susceptible clinical isolates examined in the present study
|
Isolate |
TGC* MIC (μg ml−1) |
Presence of TGC resistance determinants (mutations occurring in the protein sequence) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
|
ramR |
acrR |
oqxR |
rpsJ |
tetA |
tetX |
tetL |
tetM |
||
|
1kpn |
4 |
+ |
+ |
− |
+(V57L) |
+(S201A, F202S, V203F) |
− |
− |
− |
|
2kpn |
4 |
+(118_119ins†) |
+ |
+ |
+ |
+(S201A, F202S, V203F) |
− |
− |
− |
|
3kpn |
4 |
+(A19V, R107C) |
+ |
+ |
+(V57L, T69S) |
+(S201A, F202S, V203F) |
− |
− |
− |
|
4kpn |
4 |
+(A19V, R107C) |
+ |
+ |
+(V57L, T69S) |
+(S201A, F202S, V203F) |
− |
− |
− |
|
5kpn |
4 |
+ |
+ |
− |
+ |
+(S201A, F202S, V203F) |
− |
− |
− |
*TGC, tigecycline; †ins, insertion; +, presence of PCR product and no change in the nucleotide/amino acid sequences; −, absence of PCR product;