Fig. 2.

The p-CRMP2-to-CRMP2 ratio in lymphocytes from patients with SCZ was significantly lower than in lymphocytes from unaffected age-matched control subjects. CRMP2 phosphorylated at Serine 522 (p-CRMP2) was examined via quantitative Western blots using a specific well-authenticated antibody (SI Appendix, Fig. S1). (A) Differences were most striking between cohorts that were <30 y old (*P < 0.01). (B) Examination (in the aggregate) of the absolute values of CRMP2 (Left) and p-CRMP2 (Center) (using arbitrary values normalized to β-actin as an internal standard) shows that the p-CRMP2:CRMP2 ratio in human PBMC fractions from patients with SCZ (S) compared with unaffected controls (C) (Right) was significantly lower (P = 0.0051) because the level of CRMP2 (the denominator) was greater (P = 0.0146) while pCRMP2 remained unchanged (P = 0.4373).