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. 2021 Aug 6;4(8):e2118543. doi: 10.1001/jamanetworkopen.2021.18543

Figure 2. Headache Intensity on Vasoactive Intestinal Polypeptide and Placebo Days in 21 Patients With Migraine.

Figure 2.

The abscissa refers to the time (min). (A) Median (thick, orange line) and individual (dotted lines) headache intensity on an NRS. The orange area represents the 2-hour infusion of VIP. The AUC for headache intensity was significantly greater after VIP compared with placebo (AUC0-12h, P = .003). The median time of onset for migraine-like attacks was 1 h 40 min (IQR, 1 h to 1 h 50 min). (B) Median (thick, black line) and individual (dotted lines) headache intensity on an NRS. The light blue area represents the 2-hour infusion of placebo. NRS indicates numerical rating scale.