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. 2021 Jul 21;10(15):3199. doi: 10.3390/jcm10153199

Figure 2.

Figure 2

Close correlation between psoriasis and adipose tissue. Adipokines and proinflammatory cytokines derived from white adipose tissue (WAT) enhance and influence the Th17-mediated inflammatory response. In psoriasis and obesity, balance between proinflammatory adipokines and anti-inflammatory adipokines is dysregulated. In obese WAT, macrophages infiltrate the stromal vascular fraction of WAT via the monocyte chemoattractantprotein-1 (MCP-1)/CCR2 pathway. Adipose tissue macrophages (ATMs) activated via TLR4 stimulation by saturated fatty acids (SFAs) release proinflammatory cytokines, such as TNF and IL-6. SFAs, pathogen-associated molecular patterns (PAMPs), and danger-associated molecular patterns (DAMPs) also activate NLRP3 inflammasomes in ATMs, resulting in the enhanced production of IL-1 and IL-18. These proinflammatory cytokines synergistically work with Th17-derived cytokines to enhance systemic inflammatory responses.