14,15-EET	14,15-epoxyeicosatrienoate, vasodilating eicosonoid
15-HETE	15-hydroxyeicosatetraenoate, vasoconstricting eicosonoid
2-AG	2-arachidonoyl glycerol, endocannabinoid
5-HT	serotonin
Aβ	amyloid beta
AML	acute myeloid leukemia
BDNF	brain-derived neurotrophic factor
cAMP	cyclic adenosine monophosphate
CAD	coronary artery disease
Ca levels	calcium levels
CBR1	endocannabinoid receptor 1
CHO	cell line derived from Chinese hamster ovaries
COS-7	cell line derived from kidney of African Green Monkey
CRE	cAMP response element (CRE) transcription factor
CREB	cAMP response element-binding protein (CREB)
DAG	diacylglcerol
ECL	extracellular domain
ERK	extracellular signal-regulated kinase
Gα12/13	G-protein inositol alpha 12/13, GPR39’s constitutively active signaling cascade
Gαq	G-protein inositol alpha q, zinc-activated signaling cascade through GPR39
Gαs	G-protein inositol alpha s, zinc-activated signaling cascade through GPR39
GnR	ghrelin receptor
GPCR	G-protein coupled receptor
GPR39	G protein coupled receptor 39, also known as ZnR (zinc receptor)
GPR39-C3	synthetic agonist of GPR39, also known as C3 or TC-G 1008
HEK293T	Cell line derived from human kidney
HT	hypertension
IL-10	interleukin 10
IP3	1,3,4-triphosphate
KCC2	K+/Cl-cotransporter
KO	knock out
LPS	lipopolysaccharide (LPS), bacteria-derived compound to induce inflammatory sepsis
Lung Cap	lung capacity
LYPD1	LY6/PLAUR domain containing 1 gene, antisense gene overlapping with GPR39’s second exon, overlaps with GPR39-1a but not GPR39-1b
MAPK	mitogen-activated protein kinase
MCI	mild cognitive impairment
mVSMCs	microvascular smooth muscle cells
NHE-1	Na+/H+ exchanger
NTSR1	Neurotensin receptor 1
OE	over expression
PAM	positive allosteric modulator
PI3	phosphoinositide 3
PKA	phosphokinase A
PKB/AKT	protein kinase B/Ak-strain transforming pathways
PKC	phosphokinase C
PKIB	Protein kinase A inhibitor beta
PLC	phospholipase C
sc-RNAseq	single cell RNA sequencing
SRE	serum response element, constitutive pathway of GPR39 signaling cascade
SNRI	serotonin and norepinephrine reuptake inhibitor
SSRI	selective serotonin reuptake inhibitor
TM	transmembrane domain
TrkB	Tropomyosin receptor kinase B
VCI	vascular cognitive dementia
VCID	vascular cognitive impairment and dementia
VSMC	vascular smooth muscle cell
WT	wild type
ZnT3	zinc transporter