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. 2021 Jul 31;22(15):8273. doi: 10.3390/ijms22158273

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The pH dependence of the folding free energy of wild-type proteins and their mutants from minimized structures within pH range 4–8. (a)TYR; (b) ATP7A; (c) SLC45A2; (d) OCA2 & (e) TPC2.