Table 1.

Change in folding free energy due to variants.

Change in Folding Free Energy (ΔΔG) Due to Variants(kcal/mol)
Protein	Variant	Avg ƊΔG	SD
TYR	R402Q	−0.5	0.5
	S192 YDouble MT *	−0.27 −0.77	0.78 1.09
OCA2	A481T	−1.01	0.52
	H615L	0.17	0.39
	N489D	−1.05	1.08
	P743L	−0.9	0.45
	R419Q	−0.54	0.33
	V443I	−0.54	0.48
SLC45A2	G198V	−0.51	0.25
	L374F	−0.84	0.47
TPC2	K376R	−0.49	0.3
	M484L	−0.86	0.33
	M546I	−0.1	0.67
	V219I	−0.11	0.32
ATP7A	C1002F	−1.2	0.74
	G666R	−0.21	0.7
	D1044E	−0.8	0.53
	I1264V	−1.1	0.74
	K742R	0.01	0.35
	M1311V	−0.79	0.35
	R844C	−0.48	0.39
	S653Y	−0.45	0.54

Note: Positive and negative values of ΔΔG represent stabilization and destabilization due to the variant, respectively. The asterisk indicates a double mutant (R402Q and S192Y) for TYR, where ΔΔG was calculated by taking the sum of individual changes.