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. 2021 Jul 27;22(15):8020. doi: 10.3390/ijms22158020
2-APB 2-aminoethoxydiphenyl borate
Å angstrom (unit of length equal to 10−10 m)
aa amino acid
AKAP79 A-kinase anchor protein
ANSGA four-point mutation in hinge region aa position 261–265
ARC arachidonate regulated Ca2+ channel
BMS bis(2-mercaptoethyl)sulfone
BTP2 [N-4-[3,5-bis(Trifluoromethyl)-1H-pyrazol-1-yl]phenyl-4-methyl-1,2,3-thiadiazole-5-carboxamide]
Ca2+ calcium ion
CAD Ca2+ release-activated Ca2+-activating domain
CAR Ca2+-accumulating region
CC coiled-coil
CRAC Ca2+ release-activated Ca2+
cryo-EM cryogenic electron microscopy
Cs+ cesium ion
ΔN represents N terminal deletion mutants
dOrai Drosophila melanogaster Orai
DVF divalent-free
ER endoplasmic reticulum
ETON extended transmembrane Orai1 N-terminal
FCDI fast calcium-dependent inactivation
FRET fluorescence resonance energy transfer
GoF gain of function
GSK GlaxoSmithKline compounds
ICa2+ CRAC current
INa+ sodium current in sodium divalent-free solution
IP3 inositol triphosphate
KO Knock out
LoF loss of function
LTC4 Leukotriene C4 -regulated Ca2+ (LRC) channels
LV(SHK) hinge region aa position 261–265
MD molecular dynamics simulations
Na+-DVF sodium divalent free
NFAT nuclear factor of activated T-cells
NSCLC non-small cell lung cancer
Orai 1–3 Orai proteins (also O1–3)
PIP2 phosphatidylinositol 4,5-bisphosphate
PM plasma membrane
ROS reactive oxygen species
SAM sterile α-motif
siRNA Small interfering RNA
SOAR STIM–Orai-activating region
SPCA2 Secretory pathway Ca2+-ATPase
STIM stromal interaction molecule
Synta66 4-Pyridinecarboxamide
TM transmembrane helices
TRP transient receptor potential ion channel (C-canonical, M-melastatin, V-vallinoid)