2-APB |
2-aminoethoxydiphenyl borate |
Å |
angstrom (unit of length equal to 10−10 m) |
aa |
amino acid |
AKAP79 |
A-kinase anchor protein |
ANSGA |
four-point mutation in hinge region aa position 261–265 |
ARC |
arachidonate regulated Ca2+ channel |
BMS |
bis(2-mercaptoethyl)sulfone |
BTP2 |
[N-4-[3,5-bis(Trifluoromethyl)-1H-pyrazol-1-yl]phenyl-4-methyl-1,2,3-thiadiazole-5-carboxamide] |
Ca2+
|
calcium ion |
CAD |
Ca2+ release-activated Ca2+-activating domain |
CAR |
Ca2+-accumulating region |
CC |
coiled-coil |
CRAC |
Ca2+ release-activated Ca2+
|
cryo-EM |
cryogenic electron microscopy |
Cs+
|
cesium ion |
ΔN |
represents N terminal deletion mutants |
dOrai |
Drosophila melanogaster Orai |
DVF |
divalent-free |
ER |
endoplasmic reticulum |
ETON |
extended transmembrane Orai1 N-terminal |
FCDI |
fast calcium-dependent inactivation |
FRET |
fluorescence resonance energy transfer |
GoF |
gain of function |
GSK |
GlaxoSmithKline compounds |
ICa2+
|
CRAC current |
INa+
|
sodium current in sodium divalent-free solution |
IP3
|
inositol triphosphate |
KO |
Knock out |
LoF |
loss of function |
LTC4 |
Leukotriene C4 -regulated Ca2+ (LRC) channels |
LV(SHK) |
hinge region aa position 261–265 |
MD |
molecular dynamics simulations |
Na+-DVF |
sodium divalent free |
NFAT |
nuclear factor of activated T-cells |
NSCLC |
non-small cell lung cancer |
Orai 1–3 |
Orai proteins (also O1–3) |
PIP2
|
phosphatidylinositol 4,5-bisphosphate |
PM |
plasma membrane |
ROS |
reactive oxygen species |
SAM |
sterile α-motif |
siRNA |
Small interfering RNA |
SOAR |
STIM–Orai-activating region |
SPCA2 |
Secretory pathway Ca2+-ATPase |
STIM |
stromal interaction molecule |
Synta66 |
4-Pyridinecarboxamide |
TM |
transmembrane helices |
TRP |
transient receptor potential ion channel (C-canonical, M-melastatin, V-vallinoid) |