Table 4.
Summary of the studies included according to the cannabinoids and caries lesions.
| Cannabinoids and Caries Lesions | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Authors | Drug | Study Design | Experimental Model | Administration Protocol | Results | Test | Control | Subjects/Specimens | Study Time |
| Grafton et al. [130] | Marijuana/Tobacco Smoke | Case Report | Tooth extraction socket/Dental Caries | 5 h before the dental treatment | Low patient compliance regarding the cannabis use. | - | - | 1 subject (29 years old) | - |
| Ditmyer et al. [131] | Marijuana/Tobacco Smoke | Retrospective cohort study | Dental Caries Prevalence Screening | High prevalence/severity of dental caries in subjects with tobacco/marijuana administration | 66,941 subjects (13–18 years old) | 8 years | |||
| Liu et al. [104] | Tetrahydrocannabinol (THC) | In vitro study | Human Periodontal fibroblast (HPLF) | Cell cultures | THC promoted periodontal cell adhesion and migration through wound healing | THC 1µM | No treatment | - | 0 h, 3 h, 6 h and 24 h |