Table 1.
Vasodilator agents used for stress CMR.
| Adenosine | Dypiridamole | Regadenoson | |
|---|---|---|---|
| Potency | Less potent | 10 times more potent | |
| Receptor Selectivity | Non-selective A2 | Selective A2A | |
| Administration | Weight-based 4–6 min infusion | Weight-based 6 min infusion | Non-weight based, single dose bolus |
| Dose | 140 ug/Kg/min | 0.56–0.84 mg/Kg | 400 ug |
| Duration of Infusion | 4–6 min | 4–6 min | 10 s bolus |
| Time to Peak Plasma Concentration | 30 s | minutes | 33 s |
| Half-life | <10 s | 11 h | 30 min |
| Duration of Action | 6 s | 30 min | 2.3 min |
| HR | Smaller increase | Faster and greater increase | |
| Adverse Effects | More bronchocostriction, AVB | Less bronchocostriction, AVB |
HR, heart rate; AVB, atrio-ventricular block.