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Metabolism of canonical sphingolipids. Various different headgroups can be added to ceramide to form different classes of complex sphingolipids. SMS, sphingomyelin synthase; SMase, sphingomyelinase; GCS, glucosyl-ceramide synthase; GCase, glucosyl ceramidase; CDase, ceramidase; CerS, ceramide synthase; CK, ceramide kinase; C1PP, ceramide-1-phosphate phosphatase; SPPase, S1P phosphatase; SK, sphingosine kinase.
