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Synthesis of 1-deoxy-sphinganine (12) and 1-deoxymethyl-sphinganine (17). Reagents and conditions: (a) (i) Mg, 1,2-dibromoethane, 1-bromopentadecane, THF, 2–3 h. (ii) 2 or 14, THF, 0 °C- r.t., 2–3 h; (b) TBLAH, EtOH, −78 °C, 2–3 h; (c) AcCl, MeOH, 0 °C-r.t., 2 h.
