Table 3.

Clinical factors associated with prolonged QTc.

System	Risk Factor
Autonomic nervous system	Pheochromocytoma Head-up-tilt Pure autonomic failure Sleep deprivation
Cardiovascular disease	Bradycardia Stress cardiomyopathy Stroke Aortic stenosis
Electrolyte disorders	Hypokalemia Hypomagnesemia Hypocalcemia Gitelman syndrome Blood transfusion
Endocrine disorders	Hypothyroidism Hyperparathyroidism
Environmental effects	Hypothermia Carbon monoxide Grapefruit juice Synthetic cannabinoids
General	Female sex, age > 65,
Inflammation/auto-immune	Rheumatoid arthritis Celiac disease Ankylosing spondylitis
Miscellaneous	Genotypic association Propionic academia Liquid protein diet Sickle cell disease

Table adapted from CredibleMeds^® list of clinical factors associated with prolonged QTc, only those with high quality evidence were taken into account and listed in the table [24].